Activation of Melatonin Signaling Promotes β-Cell Survival and Function
نویسندگان
چکیده
منابع مشابه
Activation of Melatonin Signaling Promotes β-Cell Survival and Function.
Type 2 diabetes mellitus (T2DM) is characterized by pancreatic islet failure due to loss of β-cell secretory function and mass. Studies have identified a link between a variance in the gene encoding melatonin (MT) receptor 2, T2DM, and impaired insulin secretion. This genetic linkage raises the question whether MT signaling plays a role in regulation of β-cell function and survival in T2DM. To ...
متن کاملα 3 β 1 integrin promotes keratinocyte cell survival through activation of a MEK / ERK signaling pathway
In normal epithelial cells, inadequate or inappropriate cell adhesion to the extracellular matrix (ECM) leads to a specialized form of apoptosis known as anoikis (Frisch and Francis, 1994; Frisch and Screaton, 2001). Integrins are the major receptors for cell adhesion to the ECM (Hynes, 2002), and they are the principle receptors for transmitting outside-in signals from the ECM that inhibit ano...
متن کاملβ-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance
Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression. In many types of cancers nuclear translocation of beta-catenin has been observed. Our data indicate that during melanoma progression an increased dependency on the transcriptional function of beta-catenin takes pl...
متن کاملNitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2.
Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in which the multifunctional cytokine nitric oxide counterbalances TNF-alpha-induced apoptosis, to defin...
متن کاملAn islet-specific pulse of TGF-β abrogates CTL function and promotes β cell survival independent of Foxp3+ T cells.
Effective therapies that prevent chronic inflammation from developing into type 1 diabetes remain elusive. In this study, we show that expression of TGF-β for just 1 wk in inflamed islets of NOD mice significantly delays diabetes development. Time course studies demonstrated that the brief TGF-β pulse protects only if administered when extensive β cell destruction has occurred. Surprisingly, TG...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2015
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2014-1293